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Regulation of A1 by OX40 Contributes to CD8(+) T Cell Survival and Anti-Tumor Activity
The TNFR family member OX40 (CD134) is critical for optimal clonal expansion and survival of T cells. However, the intracellular targets of OX40 in CD8 T cells are not fully understood. Here we show that A1, a Bcl-2 family protein, is regulated by OX40 in effector CD8 T cells. In contrast to wild-ty...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731243/ https://www.ncbi.nlm.nih.gov/pubmed/23936461 http://dx.doi.org/10.1371/journal.pone.0070635 |