Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection

Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free heme toxicity. The parasite can also synthesize heme de novo, and all the enzymes in the pathway are characterized. To stu...

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Detalles Bibliográficos
Autores principales: Nagaraj, Viswanathan Arun, Sundaram, Balamurugan, Varadarajan, Nandan Mysore, Subramani, Pradeep Annamalai, Kalappa, Devaiah Monnanda, Ghosh, Susanta Kumar, Padmanaban, Govindarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731253/
https://www.ncbi.nlm.nih.gov/pubmed/23935500
http://dx.doi.org/10.1371/journal.ppat.1003522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731253/
https://www.ncbi.nlm.nih.gov/pubmed/23935500
http://dx.doi.org/10.1371/journal.ppat.1003522

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