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Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection
Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free heme toxicity. The parasite can also synthesize heme de novo, and all the enzymes in the pathway are characterized. To stu...
Autores principales: | Nagaraj, Viswanathan Arun, Sundaram, Balamurugan, Varadarajan, Nandan Mysore, Subramani, Pradeep Annamalai, Kalappa, Devaiah Monnanda, Ghosh, Susanta Kumar, Padmanaban, Govindarajan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731253/ https://www.ncbi.nlm.nih.gov/pubmed/23935500 http://dx.doi.org/10.1371/journal.ppat.1003522 |
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