Optimization of Substituted 6-Salicyl-4-Anilinoquinazoline Derivatives as Dual EGFR/HER2 Tyrosine Kinase Inhibitors

4-Anilinoquinazolines as an important class of protein kinase inhibitor are widely investigated for epidermal growth factor receptor (EGFR) tyrosine kinase or epidermal growth factor receptor 2 (HER2) inhibition. A series of novel 6-salicyl-4-anilinoquinazoline derivatives 9–27 were prepared and eva...

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Detalles Bibliográficos
Autores principales: Li, Dong-Dong, Qin, Ya-Juan, Sun, Jian, Li, Jing-Ran, Fang, Fei, Du, Qian-Ru, Qian, Yong, Gong, Hai-Bin, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731256/
https://www.ncbi.nlm.nih.gov/pubmed/23936329
http://dx.doi.org/10.1371/journal.pone.0069427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731256/
https://www.ncbi.nlm.nih.gov/pubmed/23936329
http://dx.doi.org/10.1371/journal.pone.0069427

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