Impaired Ca(2+) Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination

Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated. We previously generated mice lacking leptin signaling...

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Detalles Bibliográficos
Autores principales: Tudurí, Eva, Bruin, Jennifer E., Denroche, Heather C., Fox, Jessica K., Johnson, James D., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731269/
https://www.ncbi.nlm.nih.gov/pubmed/23936486
http://dx.doi.org/10.1371/journal.pone.0071075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731269/
https://www.ncbi.nlm.nih.gov/pubmed/23936486
http://dx.doi.org/10.1371/journal.pone.0071075

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