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Impaired Ca(2+) Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination
Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated. We previously generated mice lacking leptin signaling...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731269/ https://www.ncbi.nlm.nih.gov/pubmed/23936486 http://dx.doi.org/10.1371/journal.pone.0071075 |