Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac

P21-activated kinase 1 (PAK1) is activated by binding to GTP-bound Rho GTPases Cdc42 and Rac via its CRIB domain. Here, we provide evidence that S79 in the CRIB domain of PAK1 is not directly involved in this binding but is crucial for PAK1 activation. S79A mutation reduces the binding affinity of P...

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Detalles Bibliográficos
Autores principales: Shin, Yong Jae, Kim, Eun Hye, Roy, Adhiraj, Kim, Jeong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731272/
https://www.ncbi.nlm.nih.gov/pubmed/23936510
http://dx.doi.org/10.1371/journal.pone.0071495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731272/
https://www.ncbi.nlm.nih.gov/pubmed/23936510
http://dx.doi.org/10.1371/journal.pone.0071495

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