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The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

The lipid phosphatase Sac1 cycles between endoplasmic reticulum and cisternal Golgi compartments. In proliferating mammalian cells, a canonical dilysine motif at the C-terminus of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER. Starvation triggers accumula...

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Detalles Bibliográficos
Autores principales: Wang, Jinzhi, Chen, Juxing, Enns, Caroline A., Mayinger, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731292/
https://www.ncbi.nlm.nih.gov/pubmed/23936490
http://dx.doi.org/10.1371/journal.pone.0071112