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Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B and TNF) coding for these two cytokines. Prior t...
Autores principales: | Adamik, Juraj, Wang, Kent Z. Q., Unlu, Sebnem, Su, An-Jey A., Tannahill, Gillian M., Galson, Deborah L., O’Neill, Luke A., Auron, Philip E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731334/ https://www.ncbi.nlm.nih.gov/pubmed/23936458 http://dx.doi.org/10.1371/journal.pone.0070622 |
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