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Short Term Exercise Induces PGC-1α, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts
PGC-1α, a transcriptional coactivator, controls inflammation and mitochondrial gene expression in insulin-sensitive tissues following exercise intervention. However, attributing such effects to PGC-1α is counfounded by exercise-induced fluctuations in blood glucose, insulin or bodyweight in diabetic...
Autores principales: | Botta, Amy, Laher, Ismail, Beam, Julianne, DeCoffe, Daniella, Brown, Kirsty, Halder, Swagata, Devlin, Angela, Gibson, Deanna L., Ghosh, Sanjoy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731348/ https://www.ncbi.nlm.nih.gov/pubmed/23936397 http://dx.doi.org/10.1371/journal.pone.0070248 |
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