Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease

The β-secretase enzyme BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which initiates amyloid-β (Aβ) production, is an excellent therapeutic target for Alzheimer's disease (AD). However, recent evidence raises concern that BACE1-inhibiting approaches may encounter dramatic declines...

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Detalles Bibliográficos
Autores principales: Devi, L, Ohno, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731791/
https://www.ncbi.nlm.nih.gov/pubmed/23880880
http://dx.doi.org/10.1038/tp.2013.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731791/
https://www.ncbi.nlm.nih.gov/pubmed/23880880
http://dx.doi.org/10.1038/tp.2013.59

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