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Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease
The β-secretase enzyme BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which initiates amyloid-β (Aβ) production, is an excellent therapeutic target for Alzheimer's disease (AD). However, recent evidence raises concern that BACE1-inhibiting approaches may encounter dramatic declines...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731791/ https://www.ncbi.nlm.nih.gov/pubmed/23880880 http://dx.doi.org/10.1038/tp.2013.59 |