Clinical Trial Simulation to Inform Phase 2: Comparison of Concentrated vs. Distributed First-in-Patient Study Designs in Psoriasis

Clinical trial simulation (CTS) and model-based meta-analysis (MBMA) can increase our understanding of small, first-in-patient (FIP) trial design performance to inform Phase 2 decision making. In this work, we compared dose-ranging designs vs. designs testing only placebo and the maximum dose for ea...

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Detalles Bibliográficos
Autores principales: Dodds, M G, Salinger, D H, Mandema, J, Gibbs, J P, Gibbs, M A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731828/
https://www.ncbi.nlm.nih.gov/pubmed/23884206
http://dx.doi.org/10.1038/psp.2013.32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731828/
https://www.ncbi.nlm.nih.gov/pubmed/23884206
http://dx.doi.org/10.1038/psp.2013.32

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