Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

Treatment with doxorubicin (Dox) results in serious systemic toxicities that limit effectiveness for cancer treatment and cause long-term health issues for cancer patients. We identified a new DNA aptamer to prostate-specific membrane antigen (PSMA) using fixed sequences to promote Dox binding and d...

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Detalles Bibliográficos
Autores principales: Boyacioglu, Olcay, Stuart, Christopher H, Kulik, George, Gmeiner, William H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731884/
https://www.ncbi.nlm.nih.gov/pubmed/23860551
http://dx.doi.org/10.1038/mtna.2013.37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731884/
https://www.ncbi.nlm.nih.gov/pubmed/23860551
http://dx.doi.org/10.1038/mtna.2013.37

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