An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

Small noncoding antisense RNAs (sasRNAs) guide epigenetic silencing complexes to target loci in human cells and modulate gene transcription. When these targeted loci are situated within a promoter, long-term, stable epigenetic silencing of transcription can occur. Recent studies suggest that there e...

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Detalles Bibliográficos
Autores principales: Ackley, Amanda, Lenox, Alexandra, Stapleton, Kenneth, Knowling, Stuart, Lu, Tim, Sabir, Kenny S, Vogt, Peter K, Morris, Kevin V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731886/
https://www.ncbi.nlm.nih.gov/pubmed/23839098
http://dx.doi.org/10.1038/mtna.2013.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731886/
https://www.ncbi.nlm.nih.gov/pubmed/23839098
http://dx.doi.org/10.1038/mtna.2013.33

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