Tagging of Genomic STAT3 and STAT1 with Fluorescent Proteins and Insertion of a Luciferase Reporter in the Cyclin D1 Gene Provides a Modified A549 Cell Line to Screen for Selective STAT3 Inhibitors

Signal transducer and activator of transcription 3 (STAT3) is an oncogenic protein that is constitutively activated in numerous cancer cell lines and human cancers. Another STAT family member, STAT1, possesses cancer-inhibitory properties and can promote apoptosis in tumor cells upon activation. To...

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Detalles Bibliográficos
Autores principales: Samsonov, Andrey, Zenser, Nathan, Zhang, Fan, Zhang, Hongyi, Fetter, John, Malkov, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732202/
https://www.ncbi.nlm.nih.gov/pubmed/23950841
http://dx.doi.org/10.1371/journal.pone.0068391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732202/
https://www.ncbi.nlm.nih.gov/pubmed/23950841
http://dx.doi.org/10.1371/journal.pone.0068391

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