Cargando…

Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting Autophagy

Members of the Src family kinases (SFK) can modulate diverse cellular processes, including division, death and survival, but their role in autophagy has been minimally explored. Here, we investigated the roles of Lyn, a SFK, in promoting the survival of human glioblastoma tumor (GBM) cells in vitro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wei Michael, Huang, Ping, Kar, Niladri, Burgett, Monica, Muller-Greven, Gaelle, Nowacki, Amy S., Distelhorst, Clark W., Lathia, Justin D., Rich, Jeremy N., Kappes, John C., Gladson, Candece L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732228/ https://www.ncbi.nlm.nih.gov/pubmed/23936469 http://dx.doi.org/10.1371/journal.pone.0070804

Ejemplares similares

Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis
por: Bae, Eunnyung, et al.
Publicado: (2022)

Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells
por: Burgett, Monica E., et al.
Publicado: (2016)

Progress on Antiangiogenic Therapy for Patients with Malignant Glioma
por: Ahluwalia, Manmeet S., et al.
Publicado: (2010)

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma
por: Lin, Tzu-Wei, et al.
Publicado: (2017)

The 'selfish brain' is regulated by aquaporins and autophagy under nutrient deprivation
por: YE, QIAO, et al.
Publicado: (2016)

Essential Role of Lyn in Fibrosis
por: Pham, Hung, et al.
Publicado: (2016)

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy
por: Peeters, J.G.C., et al.
Publicado: (2018)

Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis
por: Li, Xuefeng, et al.
Publicado: (2016)

Awards for Lyn Evans and Philippe Lebrun
Publicado: (2007)

The LHC Adventure -- Dr. Lyn Evans
por: CERN. Geneva
Publicado: (2009)

Functions of the Lyn tyrosine kinase in health and disease
por: Ingley, Evan
Publicado: (2012)

Lyn Evans, l'homme du LHC
Publicado: (2009)

Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
por: Jiang, Chonghua, et al.
Publicado: (2022)

TRIB3 facilitates glioblastoma progression via restraining autophagy
por: Tang, Zhanbin, et al.
Publicado: (2020)

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation
por: Ribeiro, Giselle Ferreira, et al.
Publicado: (2018)

PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation
por: Rodríguez-Vargas, José Manuel, et al.
Publicado: (2019)

Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy
por: Sun, Haojie, et al.
Publicado: (2016)

Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy
por: Hu, Fei, et al.
Publicado: (2017)

DRAM‐4 and DRAM‐5 are compensatory regulators of autophagy and cell survival in nutrient‐deprived conditions
por: Barthet, Valentin J. A., et al.
Publicado: (2022)

Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
por: Chen, Weiyi, et al.
Publicado: (2023)

LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1
por: vom Stein, Alexander F., et al.
Publicado: (2023)

Cancer stem cells in glioblastoma
por: Lathia, Justin D., et al.
Publicado: (2015)

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis
por: Peikert, Kevin, et al.
Publicado: (2021)

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition
por: Jung, Samil, et al.
Publicado: (2015)

Autophagy downregulates NLRP3-dependent inflammatory response of intestinal epithelial cells under nutrient deprivation
por: Yun, Yewon, et al.
Publicado: (2021)

Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL
por: Li, Bin, et al.
Publicado: (2016)

Educational Case: Nutrient Deprivation and Anemia
por: Nickens, Caitlin, et al.
Publicado: (2019)

GPI-anchored receptor clusters transiently recruit Lyn and Gα for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1
por: Suzuki, Kenichi G.N., et al.
Publicado: (2007)

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells
por: Morinaga, Takao, et al.
Publicado: (2017)

Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells
por: Galan-Moya, Eva Maria, et al.
Publicado: (2014)

Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation
por: Tao, Jun, et al.
Publicado: (2016)

Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation
por: Chen, Man-man, et al.
Publicado: (2023)

Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity
por: Hibbs, Margaret L., et al.
Publicado: (2002)

Inhibition of the B Cell by CD22: A Requirement for Lyn
por: Smith, Kenneth G.C., et al.
Publicado: (1998)

Lyn Evans, Peter jenni, Tejinder Virdee: BIG BANG
por: Giussani, Bruno
Publicado: (2007)

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
por: Freedman, Tanya S, et al.
Publicado: (2015)

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles
por: Li, Ming Yuan, et al.
Publicado: (2020)

A dominant function of LynB kinase in preventing autoimmunity
por: Brian, Ben F., et al.
Publicado: (2022)

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation
por: Weng, Hong, et al.
Publicado: (2023)

Lyn‐mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn
por: Kong, Erliang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2lifrqvjknpvasguvdbdhg6vbt