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LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity
Currently, there is a shortage of adjuvants that can be employed with protein subunit vaccines to enhance protection against biological threats. LT-IIb(T13I) is an engineered nontoxic derivative of LT-IIb, a member of the type II subfamily of heat labile enterotoxins expressed by Escherichia coli, t...
Autores principales: | Greene, Christopher J., Chadwick, Chrystal M., Mandell, Lorrie M., Hu, John C., O’Hara, Joanne M., Brey, Robert N., Mantis, Nicholas J., Connell, Terry D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732243/ https://www.ncbi.nlm.nih.gov/pubmed/23936344 http://dx.doi.org/10.1371/journal.pone.0069678 |
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