Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye

Gaucher disease (GD) is the most common of the lysosomal storage disorders and is caused by defects in the GBA gene encoding glucocerebrosidase (GlcCerase). The accumulation of its substrate, glucocylceramide (GlcCer) is considered the main cause of GD. We found here that the expression of human mut...

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Detalles Bibliográficos
Autores principales: Suzuki, Takahiro, Shimoda, Masami, Ito, Kumpei, Hanai, Shuji, Aizawa, Hidenobu, Kato, Tomoki, Kawasaki, Kazunori, Yamaguchi, Terumi, Ryoo, Hyung Don, Goto-Inoue, Naoko, Setou, Mitsutoshi, Tsuji, Shoji, Ishida, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732251/
https://www.ncbi.nlm.nih.gov/pubmed/23936319
http://dx.doi.org/10.1371/journal.pone.0069147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732251/
https://www.ncbi.nlm.nih.gov/pubmed/23936319
http://dx.doi.org/10.1371/journal.pone.0069147

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