Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake

BACKGROUND: CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3′-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the “nicotine metabolite ratio”, NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and...

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Detalles Bibliográficos
Autores principales: Zhu, Andy Z. X., Zhou, Qian, Cox, Lisa Sanderson, Ahluwalia, Jasjit S., Benowitz, Neal L., Tyndale, Rachel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732272/
https://www.ncbi.nlm.nih.gov/pubmed/23936477
http://dx.doi.org/10.1371/journal.pone.0070938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732272/
https://www.ncbi.nlm.nih.gov/pubmed/23936477
http://dx.doi.org/10.1371/journal.pone.0070938

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