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Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER
Newly synthesized membrane proteins are queried by ubiquitin ligase complexes and triaged between degradative and nondegradative fates. The mechanisms that convert modest differences in substrate-ligase interactions into decisive outcomes of ubiquitination are not well understood. Here, we reconstit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732389/ https://www.ncbi.nlm.nih.gov/pubmed/23890821 http://dx.doi.org/10.1016/j.cell.2013.06.038 |