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KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma

KRAS mutations define a clinically-distinct subgroup of lung adenocarcinoma patients, characterized by smoking history, resistance to EGFR-targeted therapies, and adverse prognosis. Whether KRAS- mutated lung adenocarcinomas also have distinct histopathologic features is not well established. We tes...

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Detalles Bibliográficos
Autores principales: Rekhtman, Natasha, Ang, Daphne C., Riely, Gregory J., Ladanyi, Marc, Moreira, Andre L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732528/
https://www.ncbi.nlm.nih.gov/pubmed/23619604
http://dx.doi.org/10.1038/modpathol.2013.74