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X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate m...

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Detalles Bibliográficos
Autores principales: Yildirim, Eda, Sadreyev, Ruslan I., Pinter, Stefan F., Lee, Jeannie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732781/
https://www.ncbi.nlm.nih.gov/pubmed/22139016
http://dx.doi.org/10.1038/nsmb.2195