Cargando…

Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival

NEIL1 is unique among the oxidatively damaged base repair-initiating DNA glycosylases in the human genome due to its S phase-specific activation and ability to excise substrate base lesions from single-stranded DNA. We recently characterized NEIL1’s specific binding to downstream canonical repair an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hegde, Muralidhar L., Hegde, Pavana M., Arijit, Dutta, Boldogh, Istvan, Mitra, Sankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733129/ https://www.ncbi.nlm.nih.gov/pubmed/23926464 http://dx.doi.org/10.3390/biom2040564

Ejemplares similares

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
por: Rangaswamy, Suganya, et al.
Publicado: (2017)

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
por: Mitra, Joy, et al.
Publicado: (2014)

DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
por: Liu, Menghao, et al.
Publicado: (2021)

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
por: Wang, Haibo, et al.
Publicado: (2018)

8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions
por: Ba, Xueqing, et al.
Publicado: (2017)

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation
por: Ba, Xueqing, et al.
Publicado: (2014)

The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks
por: Albelazi, Mustafa S., et al.
Publicado: (2019)

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
por: Patel, Pooja R, et al.
Publicado: (2015)

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
por: Yang, Chunying, et al.
Publicado: (2017)

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma
por: Belanger, KarryAnne K., et al.
Publicado: (2016)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
por: Schomacher, Lars, et al.
Publicado: (2016)

NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
por: Hildrestrand, Gunn A., et al.
Publicado: (2021)

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration
por: Kodavati, Manohar, et al.
Publicado: (2023)

Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
por: Mitra, Joy, et al.
Publicado: (2014)

DNA glycosylases: in DNA repair and beyond
por: Jacobs, Angelika L., et al.
Publicado: (2011)

The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells
por: Sayed, Ibrahim M., et al.
Publicado: (2020)

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer
por: Shinmura, Kazuya, et al.
Publicado: (2016)

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure
por: Martin, Peter R., et al.
Publicado: (2017)

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress
por: Han, Dandan, et al.
Publicado: (2019)

Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers
por: Benítez-Buelga, Carlos, et al.
Publicado: (2017)

The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection
por: Hazra, Tapas, et al.
Publicado: (2022)

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
por: Hegde, Muralidhar L., et al.
Publicado: (2016)

Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase
por: Prakash, Aishwarya, et al.
Publicado: (2017)

A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase
por: Kakhkharova, Zarina I., et al.
Publicado: (2022)

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
por: Dutta, Arijit, et al.
Publicado: (2017)

Thermodynamics of the DNA Damage Repair Steps of Human 8-Oxoguanine DNA Glycosylase
por: Kuznetsov, Nikita A., et al.
Publicado: (2014)

New Mechanisms of DNA Repair Defects in Fused in Sarcoma–Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?
por: Wang, Haibo, et al.
Publicado: (2019)

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
por: Rolseth, Veslemøy, et al.
Publicado: (2017)

NEIL2 Protects against Oxidative DNA Damage Induced by Sidestream Smoke in Human Cells
por: Sarker, Altaf H., et al.
Publicado: (2014)

A Zinc Linchpin Motif in the MUTYH Glycosylase Interdomain Connector Is Required for Efficient Repair of DNA Damage
por: Engstrom, Lisa M., et al.
Publicado: (2014)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
por: Zhou, Jia, et al.
Publicado: (2015)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
por: Zhou, Jia, et al.
Publicado: (2015)

Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase
por: Prakash, Aishwarya, et al.
Publicado: (2016)

Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity
por: Myrup Holst, Camilla, et al.
Publicado: (2023)

Biological Functions of the DNA Glycosylase NEIL3 and Its Role in Disease Progression Including Cancer
por: Chen, Lang, et al.
Publicado: (2022)

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
por: Sengupta, Shiladitya, et al.
Publicado: (2020)

NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells
por: Aliyaskarova, Umit, et al.
Publicado: (2023)

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
por: Wang, Haibo, et al.
Publicado: (2021)

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
por: Bacolla, Albino, et al.
Publicado: (2020)

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase
por: Tomar, Rachana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rlaa9cgegtbqvl62unve97btpg