A two-step mechanism for TRF2-mediated chromosome end protection

Mammalian telomeres repress DNA damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 plays a crucial role in end-protection as it is required to suppress ATM activation an...

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Detalles Bibliográficos
Autores principales: Okamoto, Keiji, Bartocci, Cristina, Ouzounov, Iliana, Diedrich, Jolene K., Yates, John R., Denchi, Eros Lazzerini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733551/
https://www.ncbi.nlm.nih.gov/pubmed/23389450
http://dx.doi.org/10.1038/nature11873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733551/
https://www.ncbi.nlm.nih.gov/pubmed/23389450
http://dx.doi.org/10.1038/nature11873

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