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A two-step mechanism for TRF2-mediated chromosome end protection

Mammalian telomeres repress DNA damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 plays a crucial role in end-protection as it is required to suppress ATM activation an...

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Detalles Bibliográficos
Autores principales:	Okamoto, Keiji, Bartocci, Cristina, Ouzounov, Iliana, Diedrich, Jolene K., Yates, John R., Denchi, Eros Lazzerini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733551/ https://www.ncbi.nlm.nih.gov/pubmed/23389450 http://dx.doi.org/10.1038/nature11873

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