Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitored in single, (sub-)micrometer sized native...

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Detalles Bibliográficos
Autores principales: Grasso, Luigino, Wyss, Romain, Piguet, Joachim, Werner, Michael, Hassaïne, Ghérici, Hovius, Ruud, Vogel, Horst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733713/
https://www.ncbi.nlm.nih.gov/pubmed/23940670
http://dx.doi.org/10.1371/journal.pone.0070929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733713/
https://www.ncbi.nlm.nih.gov/pubmed/23940670
http://dx.doi.org/10.1371/journal.pone.0070929

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