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Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes
Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitored in single, (sub-)micrometer sized native...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733713/ https://www.ncbi.nlm.nih.gov/pubmed/23940670 http://dx.doi.org/10.1371/journal.pone.0070929 |