Cargando…
Exposure of Clinical MRSA Heterogeneous Strains to β-Lactams Redirects Metabolism to Optimize Energy Production through the TCA Cycle
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the most important pathogens both in health care and community-onset infections. The prerequisite for methicillin resistance is mecA, which encodes a β-lactam-insensitive penicillin binding protein PBP2a. A characteristic of MR...
Autores principales: | Keaton, Mignon A., Rosato, Roberto R., Plata, Konrad B., Singh, Christopher R., Rosato, Adriana E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733780/ https://www.ncbi.nlm.nih.gov/pubmed/23940684 http://dx.doi.org/10.1371/journal.pone.0071025 |
Ejemplares similares
-
TCA Cycle-Mediated Generation of ROS Is a Key Mediator for HeR-MRSA Survival under β-Lactam Antibiotic Exposure
por: Rosato, Roberto R., et al.
Publicado: (2014) -
Targeting of PBP1 by β-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains
por: Plata, Konrad B., et al.
Publicado: (2013) -
Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost
por: Roch, Melanie, et al.
Publicado: (2017) -
The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response
por: Kim, Choonkeun, et al.
Publicado: (2013) -
Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats
por: Hara, Yurie, et al.
Publicado: (2021)