Clonal Expansion Analysis of Transposon Insertions by High-Throughput Sequencing Identifies Candidate Cancer Genes in a PiggyBac Mutagenesis Screen

Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...

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Detalles Bibliográficos
Autores principales: Friedel, Roland H., Friedel, Caroline C., Bonfert, Thomas, Shi, Ruijin, Rad, Roland, Soriano, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733837/
https://www.ncbi.nlm.nih.gov/pubmed/23940809
http://dx.doi.org/10.1371/journal.pone.0072338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733837/
https://www.ncbi.nlm.nih.gov/pubmed/23940809
http://dx.doi.org/10.1371/journal.pone.0072338

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