Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells

Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism remains unclear yet. In the present study, a quantitative proteomic analysis using the mod...

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Detalles Bibliográficos
Autores principales: Wang, Jiarui, Zhang, Xuemei, Ma, Danjun, Lee, Wai-Nang Paul, Xiao, Jing, Zhao, Yingchun, Go, Vay Liang, Wang, Qi, Yen, Yun, Recker, Robert, Xiao, Gary Guishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733980/
https://www.ncbi.nlm.nih.gov/pubmed/23890079
http://dx.doi.org/10.1186/2162-3619-2-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733980/
https://www.ncbi.nlm.nih.gov/pubmed/23890079
http://dx.doi.org/10.1186/2162-3619-2-18

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