Absence of the Common Gamma Chain (γ(c)), a Critical Component of the Type I IL-4 Receptor, Increases the Severity of Allergic Lung Inflammation

The T(H)2 cytokines, IL-4 and IL-13, play critical roles in inducing allergic lung inflammation and drive the alternative activation of macrophages (AAM). Although both cytokines share receptor subunits, IL-4 and IL-13 have differential roles in asthma pathogenesis: IL-4 regulates T(H)2 cell differe...

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Detalles Bibliográficos
Autores principales: Dasgupta, Preeta, Qi, Xiulan, Smith, Elizabeth P., Keegan, Achsah D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734063/
https://www.ncbi.nlm.nih.gov/pubmed/23940740
http://dx.doi.org/10.1371/journal.pone.0071344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734063/
https://www.ncbi.nlm.nih.gov/pubmed/23940740
http://dx.doi.org/10.1371/journal.pone.0071344

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