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Absence of the Common Gamma Chain (γ(c)), a Critical Component of the Type I IL-4 Receptor, Increases the Severity of Allergic Lung Inflammation
The T(H)2 cytokines, IL-4 and IL-13, play critical roles in inducing allergic lung inflammation and drive the alternative activation of macrophages (AAM). Although both cytokines share receptor subunits, IL-4 and IL-13 have differential roles in asthma pathogenesis: IL-4 regulates T(H)2 cell differe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734063/ https://www.ncbi.nlm.nih.gov/pubmed/23940740 http://dx.doi.org/10.1371/journal.pone.0071344 |