Cargando…
DNA structure-specific priming of ATR activation by DNA-PKcs
Three phosphatidylinositol-3-kinase–related protein kinases implement cellular responses to DNA damage. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and ataxia-telangiectasia mutated respond primarily to DNA double-strand breaks (DSBs). Ataxia-telangiectasia and RAD3-related (ATR) signa...
Autores principales: | Vidal-Eychenié, Sophie, Décaillet, Chantal, Basbous, Jihane, Constantinou, Angelos |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734074/ https://www.ncbi.nlm.nih.gov/pubmed/23897887 http://dx.doi.org/10.1083/jcb.201304139 |
Ejemplares similares
-
Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling
por: Kumbhar, Ramhari, et al.
Publicado: (2018) -
ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022) -
PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway
por: Lin, Yu-Fen, et al.
Publicado: (2018) -
An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells
por: Alghoul, Emile, et al.
Publicado: (2021) -
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling
por: Dibitetto, Diego, et al.
Publicado: (2020)