XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells

BACKGROUND: The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis...

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Detalles Bibliográficos
Autores principales: Minks, Jakub, Baldry, Sarah EL, Yang, Christine, Cotton, Allison M, Brown, Carolyn J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734131/
https://www.ncbi.nlm.nih.gov/pubmed/23915978
http://dx.doi.org/10.1186/1756-8935-6-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734131/
https://www.ncbi.nlm.nih.gov/pubmed/23915978
http://dx.doi.org/10.1186/1756-8935-6-23

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