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XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
BACKGROUND: The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734131/ https://www.ncbi.nlm.nih.gov/pubmed/23915978 http://dx.doi.org/10.1186/1756-8935-6-23 |