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Arf Induction by Tgfβ Is Influenced by Sp1 and C/ebpβ in Opposing Directions
Recent studies show that Arf, a bona fide tumor suppressor, also plays an essential role during mouse eye development. Tgfβ is required for Arf promoter activation in developing mouse eyes, and its capacity to induce Arf depends on Smads 2/3 as well as p38 Mapk. Substantial delay between activation...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734170/ https://www.ncbi.nlm.nih.gov/pubmed/23940569 http://dx.doi.org/10.1371/journal.pone.0070371 |