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Arf Induction by Tgfβ Is Influenced by Sp1 and C/ebpβ in Opposing Directions

Recent studies show that Arf, a bona fide tumor suppressor, also plays an essential role during mouse eye development. Tgfβ is required for Arf promoter activation in developing mouse eyes, and its capacity to induce Arf depends on Smads 2/3 as well as p38 Mapk. Substantial delay between activation...

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Detalles Bibliográficos
Autores principales:	Zheng, Yanbin, Devitt, Caitlin, Liu, Jing, Iqbal, Nida, Skapek, Stephen X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734170/ https://www.ncbi.nlm.nih.gov/pubmed/23940569 http://dx.doi.org/10.1371/journal.pone.0070371

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