Fatty Acid Amide Hydrolase-Dependent Generation of Antinociceptive Drug Metabolites Acting on TRPV1 in the Brain

The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol’s antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a...

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Detalles Bibliográficos
Autores principales: Barrière, David A., Mallet, Christophe, Blomgren, Anders, Simonsen, Charlotte, Daulhac, Laurence, Libert, Frédéric, Chapuy, Eric, Etienne, Monique, Högestätt, Edward D., Zygmunt, Peter M., Eschalier, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734263/
https://www.ncbi.nlm.nih.gov/pubmed/23940628
http://dx.doi.org/10.1371/journal.pone.0070690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734263/
https://www.ncbi.nlm.nih.gov/pubmed/23940628
http://dx.doi.org/10.1371/journal.pone.0070690

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