Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model

Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotoxicity. Iron chelators and other antioxidants have not completely succeeded in mitigating this effect. One hindrance to the development of cardioprotectants is the lack of physiologically-relevant anim...

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Detalles Bibliográficos
Autores principales: Dickey, Jennifer S., Gonzalez, Yanira, Aryal, Baikuntha, Mog, Steven, Nakamura, Asako J., Redon, Christophe E., Baxa, Ulrich, Rosen, Elliot, Cheng, Gang, Zielonka, Jacek, Parekh, Palak, Mason, Karen P., Joseph, Joy, Kalyanaraman, Balaraman, Bonner, William, Herman, Eugene, Shacter, Emily, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734284/
https://www.ncbi.nlm.nih.gov/pubmed/23940596
http://dx.doi.org/10.1371/journal.pone.0070575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734284/
https://www.ncbi.nlm.nih.gov/pubmed/23940596
http://dx.doi.org/10.1371/journal.pone.0070575

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