Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

Mutations in the daf-2 gene of the conserved Insulin/Insulin-like Growth Factor (IGF-1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf-16. To uncover regulatory mechanisms coordinating this...

Descripción completa

Detalles Bibliográficos
Autores principales: Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734508/
https://www.ncbi.nlm.nih.gov/pubmed/23820781
http://dx.doi.org/10.1038/msb.2013.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734508/
https://www.ncbi.nlm.nih.gov/pubmed/23820781
http://dx.doi.org/10.1038/msb.2013.35

Ejemplares similares