Kinetics and Epigenetics of Retroviral Silencing in Mouse Embryonic Stem Cells Defined by Deletion of the D4Z4 Element

Retroviral vectors are silenced in embryonic stem (ES) cells by epigenetic mechanisms whose kinetics are poorly understood. We show here that a 3′D4Z4 insulator directs retroviral expression with persistent but variable expression for up to 5 months. Combining an internal 3′D4Z4 with HS4 insulators...

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Detalles Bibliográficos
Autores principales: Rival-Gervier, Sylvie, Lo, Mandy YM, Khattak, Shahryar, Pasceri, Peter, Lorincz, Matthew C, Ellis, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734652/
https://www.ncbi.nlm.nih.gov/pubmed/23752310
http://dx.doi.org/10.1038/mt.2013.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734652/
https://www.ncbi.nlm.nih.gov/pubmed/23752310
http://dx.doi.org/10.1038/mt.2013.131

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