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Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin

Mitotic catastrophe is an oncosuppressive mechanism that senses mitotic failure leading to cell death or senescence. As such, it protects against aneuploidy and genetic instability, and its induction in cancer cells by exogenous agents is currently seen as a promising therapeutic end point. Apoptin,...

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Detalles Bibliográficos
Autores principales: Lanz, H L, Zimmerman, R M E, Brouwer, J, Noteborn, M H M, Backendorf, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734808/
https://www.ncbi.nlm.nih.gov/pubmed/23392175
http://dx.doi.org/10.1038/cddis.2013.2