Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects

Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, R, Deedigan, L, Albarenque, S M, Mohr, A, Zwacka, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734822/
https://www.ncbi.nlm.nih.gov/pubmed/23429289
http://dx.doi.org/10.1038/cddis.2013.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734822/
https://www.ncbi.nlm.nih.gov/pubmed/23429289
http://dx.doi.org/10.1038/cddis.2013.19

Ejemplares similares