Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells

The potent and selective proteasome inhibitor bortezomib has shown remarkable antitumor activity and is now entering clinical trials for several cancers. However, the molecular mechanisms by which bortezomib induces cytotoxicity in ovarian cancer cells still remain unclear. In this study, we show th...

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Detalles Bibliográficos
Autores principales: Kao, C, Chao, A, Tsai, C L, Lin, C Y, Chuang, W C, Chen, H W, Yen, T C, Wang, T H, Lai, C H, Wang, H S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734825/
https://www.ncbi.nlm.nih.gov/pubmed/23449448
http://dx.doi.org/10.1038/cddis.2013.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734825/
https://www.ncbi.nlm.nih.gov/pubmed/23449448
http://dx.doi.org/10.1038/cddis.2013.38

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