HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

The identification of recurrent somatic mutations in genes encoding epigenetic enzymes has provided a strong rationale for the development of compounds that target the epigenome for the treatment of cancer. This notion is supported by biochemical studies demonstrating aberrant recruitment of epigene...

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Detalles Bibliográficos
Autores principales: Bolden, J E, Shi, W, Jankowski, K, Kan, C-Y, Cluse, L, Martin, B P, MacKenzie, K L, Smyth, G K, Johnstone, R W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734831/
https://www.ncbi.nlm.nih.gov/pubmed/23449455
http://dx.doi.org/10.1038/cddis.2013.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734831/
https://www.ncbi.nlm.nih.gov/pubmed/23449455
http://dx.doi.org/10.1038/cddis.2013.9

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