HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway

Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are widely used cholesterol-lowering drugs. Convincing evidence indicates that statins stimulate apoptotic cell death in several types of proliferating tumor cells in a cholesterol-lowering-independent manner. The...

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Detalles Bibliográficos
Autores principales: Qi, X-F, Zheng, L, Lee, K-J, Kim, D-H, Kim, C-S, Cai, D-Q, Wu, Z, Qin, J-W, Yu, Y-H, Kim, S-K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734846/
https://www.ncbi.nlm.nih.gov/pubmed/23449454
http://dx.doi.org/10.1038/cddis.2013.44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734846/
https://www.ncbi.nlm.nih.gov/pubmed/23449454
http://dx.doi.org/10.1038/cddis.2013.44

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