Resistance to Neuraminidase Inhibitors Conferred by an R292K Mutation in a Human Influenza Virus H7N9 Isolate Can Be Masked by a Mixed R/K Viral Population

We characterized the A/Shanghai/1/2013 virus isolated from the first confirmed human case of A/H7N9 disease in China. The A/Shanghai/1/2013 isolate contained a mixed population of R (65%; 15/23 clones) and K (35%; 8/23 clones) at neuraminidase (NA) residue 292, as determined by clonal sequencing. A/...

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Detalles Bibliográficos
Autores principales: Yen, H.-L., McKimm-Breschkin, J. L., Choy, K.-T., Wong, D. D. Y., Cheung, P. P. H., Zhou, J., Ng, I. H., Zhu, H., Webby, R. J., Guan, Y., Webster, R. G., Peiris, J. S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735122/
https://www.ncbi.nlm.nih.gov/pubmed/23860768
http://dx.doi.org/10.1128/mBio.00396-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735122/
https://www.ncbi.nlm.nih.gov/pubmed/23860768
http://dx.doi.org/10.1128/mBio.00396-13

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