Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus

Streptococcus pyogenes (group A Streptococcus [GAS]) causes ~700 million human infections/year, resulting in >500,000 deaths. There is no commercial GAS vaccine available. The GAS surface protein arginine deiminase (ADI) protects mice against a lethal challenge. ADI is an enzyme that converts arg...

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Detalles Bibliográficos
Autores principales: Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Chhatwal, G. Singh, Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan, Walker, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735194/
https://www.ncbi.nlm.nih.gov/pubmed/23919999
http://dx.doi.org/10.1128/mBio.00509-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735194/
https://www.ncbi.nlm.nih.gov/pubmed/23919999
http://dx.doi.org/10.1128/mBio.00509-13

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