Effects of the Dopamine D2 Allosteric Modulator, PAOPA, on the Expression of GRK2, Arrestin-3, ERK1/2, and on Receptor Internalization

The activity of G protein-coupled receptors (GPCRs) is intricately regulated by a range of intracellular proteins, including G protein-coupled kinases (GRKs) and arrestins. Understanding the effects of ligands on these signaling pathways could provide insights into disease pathophysiologies and trea...

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Detalles Bibliográficos
Autores principales: Basu, Dipannita, Tian, Yuxin, Bhandari, Jayant, Jiang, Jian Ru, Hui, Patricia, Johnson, Rodney L., Mishra, Ram K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735488/
https://www.ncbi.nlm.nih.gov/pubmed/23940634
http://dx.doi.org/10.1371/journal.pone.0070736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735488/
https://www.ncbi.nlm.nih.gov/pubmed/23940634
http://dx.doi.org/10.1371/journal.pone.0070736

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